Psoriasis is a chronic inflammatory skin disease that is non-infectious and characterized by well-defined reddish plaques coated in silvery-white scales. It is frequently associated with psoriasis. Usually, the scalp and extensor surfaces are where these lesions show up. Because of its obvious and frequently upsetting look, the illness can have a substantial impact on social and emotional well-being in addition to physical suffering. Mahakushtha and Kshudrakushtha are the two categories of Kushtha in Ayurveda. Once more, Kshudrakushtha was classified into eleven varieties, and Mahakushtha into seven. Ekkustha is one of the eleven varieties. Despite being classified under kushta, Ekakushtha shares the same etiology, etiopathogenesis, and treatment. The three doshas, or "Sapta dravya," Tvak, Rakta, Mamsa, and Lasika, are crucial to the etiopathogenesis of Kushtha and Ekakushtha, which is dominated by Vata Kapha Dosha. Features like Aruna varna (reddish staining), Matsyashakalopamam (fish-scale-like lesions), Mahavastu (extensive spread), and Aswedanam (lack of sweating) are characteristics that identify Ekakushtha, which is categorized under Kshudra Kushtha. Monitoring with the Psoriasis Area and Severity Index (PASI) is a common part of clinical evaluation. This article aims to establish a connection between the contemporary biological viewpoint on psoriasis and the Ayurvedic knowledge of Ekakushtha, including its etiology (Nidana), pathogenesis (Samprapti), and therapy (Chikitsa). To prove this connection, a thorough analysis of current scientific research and traditional Ayurvedic writings was done. Ayurvedic treatment concepts, which may provide a comprehensive and long-lasting method of managing Ekakustha, place an emphasis on purifying therapies (Shodhana), palliative measures (Shamana), dietary restriction, and lifestyle changes.