Introduction Infertility is defined as inability to conceive after 12 months of unprotected sexual intercourse. Infertility can be attributed primarily to male factors in 25%, female factors in 58% and is unexplained in about 17% of couples. Infertility associated with Poly Cystic Ovarian Syndrome is a major cause of concern in present generation among the reproductive age groups due to undesirable lifestyle changes. In Ayurveda primary infertility can be correlated with Anapatya type of Vandhyatva and its causative factor PCOS can be correlated with Nashtaartava as per Sushrut and Pushpaghnijataharni as per Kashyap. Treatment plan included both Shodhana and Shamana therapies. Methodology A case of 30-year-old women diagnosed with PCOS who had been struggling with infertility for 6 years having complaints of irregular periods, weight gain and increasing facial hairs. The Ayurvedic treatment protocol employed in this study included Virechana and Yogabasti procedures, followed by three cycles of Uttarabasti. In addition Abhyantara medications were administered to support systemic balance. The therapeutic plan was complemented with dietary modifications, lifestyle adjustments and stress management techniques to enhance overall efficacy and sustainability of outcomes. Result Patient conceived after treatment. Discussion Infertility is a serious health issue which impacts on couples. PCOS is one of leading cause of infertility primarily due to chronic anovulation and hormonal imbalance. Our management focuses on Agnideepana, Medohara and Artavajanana through Shodhana and Shamana Chikitsa. Conclusion This case highlights the potential efficacy of Ayurvedic interventions in managing infertility related to PCOS and emphasizes the importance of an integrative approach in healthcare.