Infertility is a serious disorder that is characterized by the absence of fecundity in an individual. Infertility is a growing concern worldwide, with approximately 15% of couples struggling to conceive. The liver is a crucial organ that regulates many important functions, including metabolism, immune system, storage, and secretion. Recent research has highlighted the association between liver disorders and infertility, particularly in the context of non-alcoholic fatty liver disease (NAFLD). This article reviews the current understanding of the relationship between liver disorders and infertility, with a focus on Ayurvedic management strategies. It also reviews the recent studies conducted on living creatures concerning liver disorders and infertility. A study conducted on a Japanese flounder to assess reproductive and liver health showed a significant relationship between them (1). It reveals that hepatic dysfunction can disrupt the metabolism of reproductive hormones, such as testosterone and estrogen, leading to hormonal imbalances and impaired reproductive function (5). Non-Alcoholic Fatty Liver Disease, in particular, has been linked to infertility in both men and women (6,7). Additionally, liver disease has been linked to oxidative stress, inflammation, and mitochondrial dysfunction, all of which can negatively impact reproductive outcomes (8). A comprehensive literature review was conducted to identify recent research on the topic, and the findings suggest that Ayurvedic interventions, including diet, lifestyle modifications, and herbal remedies, may be beneficial in improving reproductive outcomes in individuals with liver disorders (9,10).