Objective: To bridge the gap between ancient wisdom and contemporary science by exploring how Ratrijagarana, when viewed through the Ayurvedic lens, leads to Hrudroga (cardiac disorders) and how holistic Ayurvedic approaches can aid in its prevention and management. Data Source: Classical Ayurvedic texts such as Charaka Samhita, Sushruta Samhita, Ashtanga Hrudaya, and their commentaries; research articles focusing on sleep physiology, circadian disruption, and cardiovascular risk. Review Methods: A comprehensive qualitative review approach was adopted, combining classical Ayurvedic literature analysis with modern scientific evidence. Collected data were utilized and analyzed to understand the effect of Ratriijagarana on cardiovascular health and draw meaningful conclusions. Result and Conclusion: Ayurveda identifies Nidra as Trayopastambha and its disturbance as a trigger for Vata and Pitta vitiation. It induces an intense form of physiological stress, disturbing the normal functioning of the Hrudaya and eventually leading to Hrudroga. Chronic sleep deprivation elevates sympathetic nervous system activity, promotes systemic inflammation, impairs endothelial function, and increases cortisol levels. These pathophysiological changes are strongly linked with hypertension, arrhythmias, myocardial ischemia, and metabolic disorders. In young adults, increased nightlife is increasing the risk for myocardial infarction; the derangement of Doshas due to Ratrijagarana reflects the same hormonal irregularities observed in insomniacs and those engaged in night shift duties. An integrative preventive approach—emphasizing proper sleep, physical and external therapies, and lifestyle regulation—may offer effective solutions in cardiovascular risk management.