Galagandāghna Rasa1 is a classical Rasauṣadhi described in Rasendra Sambhava by Vaidya Vishwanath Dwivedi and is traditionally indicated in pathological conditions characterized by abnormal glandular enlargements, including Gandamālā, Granthi,Apachi, and Arbuda. The formulation is composed of RasaSindūra (1 Pala), Triphalā (3 Pala), Trikatu (6 Pala), and Shuddha Guggulu in an amount equal to the total weight of the above ingredients (10 Pala). The blended mixture undergoes seven days of Mardana with Kañchanāra Twak Kaṣāya as the Bhavana Dravya. The pharmacological properties attributed to this formulation Kaphahara, Medoghna, Lekhana, Śothahara, and Srotoshodhaka justify its therapeutic utility in reducing glandular swelling and regulating deranged metabolic processes. In contemporary clinical correlation, the condition described in classical texts resembles hypothyroidism, which commonly presents with reduced tissue metabolism and compensatory glandular hypertrophy. This review consolidates the classical references, probable pharmacodynamic mechanisms, and therapeutic significance of Galagandāghna Rasa, establishing it as a potent Rasauṣadhi for disease conditions rooted in MedoDhātuDuṣṭi, particularly Galaganda, Gandamālā, Granthi, Apachi, and Arbuda.