Kroshtukasheersha is classified under Vatavyadhi in Ayurveda; however, both Vata and Rakta doshas play a significant role in its pathogenesis. The condition predominantly affects the knee joint, presenting clinically with swelling resembling the head of a jackal, accompanied by intense pain that hampers ambulation. It may be correlated with synovitis of the knee joint with effusion in modern medicine. Conventional management includes the use of NSAIDs, Corticosteroids, and Arthrocentosis. In Ayurveda, Raktamokshana, particularly in the form of Jalaukavacharana (Leech therapy), is considered the most effective line of treatment. A 47-year-old male patient came to the outpatient department of Panchakarma with chief complaints of severe pain and swelling in the left knee joint persisting for two months. The patient underwent Raktamokshana via Jalaukavacharana in two sittings at seven-day intervals over the affected knee. Additionally, he was administered Punarnavadi Guggulu 500 mg and Tablet Grab 500 mg, both twice daily for 15 days. Following treatment, the patient reported approximately 80% relief in symptoms, including pain and swelling, along with marked improvement in mobility.