Medicinal plant's playing a significant role in curing various diseases from ancient times. Enicostemma littorale blume is chosen for the present study is the rational being the plant is sustainable weed which may be available in quantities of phytochemical analysis, The bitter natural plant which is important indigenous medicine. The leaf and root extract of Enicostemma littorale blume family is Gentianaceae the plant are bitter in taste and it's also various elements founds suitable for diseases majorly laxative, tooth decay, fever obesity, skin disease, wound healing, abdominal lever disorder, blood purification, snake bite, regulation the blood sugar level. E. littorale blume cosmopolitan species found in India. The study aimed to authentically identify & littoral through morphological characterization it also determines bioactive components quantities, this plant report attributes some medicinal properties. Evaluation serves as tool for quality assessment of the drug. The culture of ayurveda is deeply rooted in Indian soil. It as become the lifestyle of people since ancient times. The literature explorer's plentiful medicinal plants being used to cure many diseases. It also called as Nahi, nay in several local languages it prominently found in forest and coastal region of India. The plants also contain minerals like's calcium, iron, potassium and moreover, they possess significant anti-microbial, anti-inflammatory, anti-diabetic, anti-ulcer, anti-oxidant properties.