Helicteres isora L., commonly known as the Indian screw tree, is a well-known medicinal plant widely used in traditional systems such as Ayurveda and Siddha. Various parts of the plant, particularly the fruits and bark, have been employed in folk medicine for the treatment of gastrointestinal disorders including diarrhea, dysentery, and intestinal spasms. Phytochemical investigations reveal the presence of bioactive compounds such as flavonoids, tannins, alkaloids, saponins, and sterols, which are believed to contribute to its pharmacological actions. Experimental studies have demonstrated significant anti-diarrheal activity, attributed to the inhibition of intestinal motility and fluid secretion, as well as antibacterial effects against enteric pathogens. Similarly, antispasmodic effects have been observed in isolated tissue models, suggesting calcium channel blockade and modulation of smooth muscle contraction as possible mechanisms. These findings provide scientific support for the traditional use of H. isora in managing gastrointestinal disorders.