A Nanoemul gel is a topical gel that contains a nanoemulsion dispersed within a gel matrix. The nanoemulsion is typically prepared using high shear mixing techniques and contains droplets of an oil[8] phase dispersed in an aqueous phase stabilized by surfactants or stabilizers. The resulting Nanoemul gel has several advantages over traditional emulsion-based gels, including improved stability, enhanced drug penetration, and increased bioavailability. Nanoemul gels have been studied for their potential in dermatology and drug delivery applications, showing promising results in reducing acne lesions and improving skin appearance, as well as enhancing drug delivery and reducing inflammation. Further research is needed to optimize the formulation and assess the safety and effectiveness of Nanoemul gels for different applications. Nanoemulgel consist two different systems in which drug containing nanoemulsionis incorporated into a gel base. The fusion of these two systems makes this formulation advantageous in several ways. Lipophilic drugs can be easily incorporated and the skin permeability of the incorporated drugs can be enhanced in several folds due to the finely distributed in gel phase. Simultaneously, it can be targeted more specifically to the site of action and can avoid first pass metabolism and relieve the user. The nanoemulgel formulation related intervention to improve drug absorption and therapeutic profile of lipophilic drugs. An increasing trend in nanoemulgel use in recent years has been noticed because of the better acceptability of the preparation to the patients due to their non-greasy, convenience spreadability, and easy applicability and good therapeutic and safety profile.