Bronchial asthma is a chronic inflammatory disorder of the airways characterized by reversible airway obstruction, bronchial hyper responsiveness and recurrent episodes of wheeze and dyspnoea. In Ayurveda, it is correlated with Tamaka Swasa, caused by vitiation of Vata and Kapha in the Pranavaha Srotas. Kulathaguda is a classical Avaleha formulation described in Chakradatta under Hikka Swasa Adhikara, indicated in Tamaka Swasa, Kasa, Jwara and Hikka. In the present study, Kulathaguda was prepared by classical methods and its broncho protective activity was evaluated on histamine induced bronchospasm in guinea pigs. Eighteen healthy guinea pigs were divided into three groups (n=6): Group I – Control (normal saline), Group II – Standard (Cetirizine 1 mg/kg p.o.) and Group III – Trial (Kulathaguda 1000 mg/kg p.o.). Drugs were administered for 14 days; on day 14, animals were exposed to 1% histamine aerosol and pre convulsive time (PCT) was recorded before and after treatment. Kulathaguda produced significant delay in onset of pre convulsive dyspnoea compared to control, with 48.49% protection, which was comparable to Cetirizine (46.33%). The increase in PCT in trial and standard groups was highly significant (p<0.001) versus control. No toxicity or abnormal behaviour was observed during acute toxicity and treatment period. Thus, Kulathaguda shows promising broncho protective activity in histamine induced bronchospasm in guinea pig and may be beneficial in the management of Tamaka Swasa (bronchial asthma).