Prameha, an Ashtamahagada, arises due to Santarpana Nidanas involving ten Dushyas and progresses to Madhumeha. Improper management leads to complications in the form of Prameha Pidaka, which may further develop into Madhumehajanya Dusta Vrana, characterized by delayed healing and foul-smelling wounds. Diabetic foot ulcer (DFU) is a serious complication of diabetes mellitus. Diabetic foot ulcer is one of the most common complications of diabetes mellitus and carries a poor prognosis due to microvascular and macrovascular changes resulting from uncontrolled blood glucose levels. In this case study, 54-year-old male patient, known case of uncontrolled diabetes mellitus since 12 years, complains of non-healing ulcer over the mid plantar aspect of the right foot, pricking sensation and numbness in bilateral foot and discharge with slight bleeding, pus, foul smell. Swelling over the lateral aspect of the right foot since one and half year. Burning sensation of the bilateral foot occasionally. The management of diabetic foot ulcer includes multimodal approaches like infection control, debridement of wound, vascular assessment and proper wound care. The patient was treated on the line of Ubhayaparimarjanachikitsa. Anthaparimarjana chikitsa: Shodhana Chikitsa: Snehapana with Guggulu Tiktaka Gritha followed by Virechana, Shamana Chikitsa: Nimbadi Guggulu, Shiva Gutika, Triphala guggulu, Cap. Grab, etc. Bahirparimarjana Chiktsa: Jaloukavacharana, Vranaharin and Jatyadi Taila for wound packing. The ulcer was effectively managed through Ayurveda intervention, resulting in significant improvement in clinical signs, symptoms.