Infertility is a growing reproductive health problem with multifactorial etiology. Hyperprolactinemia is a well-established endocrine cause of anovulatory infertility. Ayurvedic classics describe the role of Kṣhiravaha Naḍi (Stanyavaha Srotas) and its vitiation by Vata in the pathogenesis of reproductive disorders. Acharya Harita has specifically mentioned that Vata vitiating the Kṣhiravaha Naḍi leads to functional derangement of Stanya, which indirectly affects fertility. The present conceptual study aims to establish a correlation between Harita’s description and modern hyperprolactinemia-induced infertility. A detailed analysis of Ayurvedic samprapti and modern endocrinological mechanisms reveals strong similarities in pathogenesis. Excess Stanya formation leads to Artava Kṣhaya and Vandhyatva in Ayurveda, which is comparable to prolactin-mediated suppression of ovulation in contemporary medicine. This study highlights the integrative relevance of classical Ayurvedic concepts in understanding endocrine infertility presenting a case series with 10 patients with infertility and raised prolactin levels .