Vidangadi Guggulu is a classical polyherbal Guggulu Vati formulation described in Chakradatta (Vrana Śoṭha Adhikāra 44/69–70) and indicated in Duṣṭa Vraṇa, Āpachi, Meha, Kuṣṭha, and Nāḍī Vraṇa. The present study aimed to standardize its pharmaceutical preparation and to establish a comprehensive analytical profile in accordance with contemporary quality control norms. Vidangadi Guggulu was prepared following the classical Vati Kalpanā method and evaluated for organoleptic characteristics, physicochemical parameters, preliminary phytochemical profile, chromatographic pattern, and microbial load. The prepared formulation consisted of uniform, brownish-black Vatis with characteristic odour and taste, reflecting classical therapeutic attributes in a stable and patient-friendly dosage form. The study concludes that Vidangadi Guggulu Vati is a safe and standardized Āyurvedic formulation, supporting its classical indications and providing a scientific basis for future pharmacological evaluation and potential application in Madhumeha.