Prameha is a metabolic disorder characterized by Kapha-Meda predominance and Kleda vriddhi, which may progress to Vata involvement in chronic stages, resulting in Madhumeha. Long-standing Prameha can further lead to complications such as Prameha Pidika due to Dushya dushti at tissue level [2]. Vidangadi Guggulu is a classical Ayurvedic formulation indicated in Prameha and related conditions. The present article aims to conceptually evaluate the role of Vidangadi Guggulu in Prameha and Prameha Pidika with reference to Ayurvedic Samprapti and Samprapti-vighatana. The study is based on classical Ayurvedic literature.