Autoimmune disorders represent a spectrum of conditions characterized by an aberrant immune response against the body’s own tissues, and their manifestation on the skin, such as in perioral dermatitis, highlights the complex interplay between systemic immunity and local inflammatory processes. Ayurveda interprets autoimmune tendencies through concepts like Agnimandya, Ama formation, Dosha imbalance—primarily Vata and Pitta—and impaired Rasavaha and Raktavaha Srotas. Perioral dermatitis, viewed as a Pittaja-Kapha predominant skin disorder with underlying Ama and immune dysregulation, aligns with Ayurvedic principles that link gut health, stress, dietary habits, and impaired Ojas to dermatological flare-ups. Integrative Ayurvedic management, including Shodhana (detoxification), Shamana (pacifying therapies), herbal formulations with immunomodulatory (Rasayana) and anti-inflammatory properties, along with diet and lifestyle corrections, helps restore immune balance and strengthen Ojas. These interventions not only address the root causes but also reduce recurrence, improve skin barrier function, and support systemic immune harmony, demonstrating significant therapeutic potential in autoimmune-associated perioral dermatitis. Over the course of treatment patient got significant relief without any side effects there was no recurrence of symptoms reported even after one year of treatment. This successful outcome underscores the efficacy and safety of Ayurveda interventions in managing Autoimmune disease , aligning with the holistic approach of addressing underlying imbalances in the body's constitution