Thyroid disorders constitute one of the most prevalent endocrine abnormalities globally. Among the available diagnostic markers, Thyroid-stimulating hormone (TSH) remains the most sensitive and practical indicator of thyroid gland function, owing to its central regulatory role in the hypothalamic–pituitary–thyroid (HPT) axis. The rising burden of endocrine disorders, including thyroid dysfunction, has been strongly associated with sedentary lifestyles and improper dietary habits. From an Ayurvedic perspective, several Kaphaja Nanatmaja Vikaras exhibit clinical features that closely resemble hypothyroidism. As a multisystem disorder, hypothyroidism demands an integrative and multimodal therapeutic approach. In the present case, Sodhana Chikitsa was employed to address the underlying pathophysiology. Notably patient achieved symptomatic relief. Laboratory investigations confirmed sustained clinical improvement following the intervention.