Infertility is a prevalent reproductive health concern affecting approximately 10–15% of couples globally and is associated with significant psychosocial stress and reduced quality of life [1]. Female factors such as ovulatory dysfunction and ovarian cysts constitute a major proportion of infertility cases [2]. Ayurveda describes infertility under the concept of Vandhyatva, attributed to vitiation of Doshas affecting Artava and Artavavaha Srotas [3]. This case report presents a 21-year-old female with primary infertility and ovarian cyst managed successfully with Panchakarma therapy, including Virechana and Yogabasti, followed by Shamana Chikitsa. Restoration of ovulation was confirmed by follicular study, and natural conception was achieved within three months. The case demonstrates the clinical utility of classical Ayurvedic management in infertility associated with ovarian pathology.