Chronic Kidney Disease (CKD) poses a significant global health burden, affecting approximately 13% of the adult population and ranking as the 8th leading cause of death in India. Despite advances in biomedical science, the progressive and multifactorial nature of CKD continues to challenge conventional therapeutic strategies. In this context, Ayurveda a traditional Indian system of medicine rooted in holistic principles offers a promising complementary perspective for CKD management. Objective: This conceptual article aims to explore the untapped potential of Ayurveda in understanding and managing CKD, through a multidisciplinary lens that integrates classical Ayurvedic wisdom with contemporary clinical insights. Methods and Scope: The methodology involved scrutinizing classical Ayurveda texts and meticulously examining pertinent scientific databases, including PubMed, Google Scholar, and the AYUSH Research Portal. This quest employed MeSH (Medical Subject Headings) terms and keywords to identify clinical trials employing Ayurvedic medicine/therapy as an intervention within the context of CKD Conclusion: By bridging traditional Ayurvedic knowledge with modern nephrology, this article advocates for a more integrative, patient-centric approach to CKD care. This synergistic model holds the potential to enhance clinical outcomes, improve quality of life, and contribute to the development of sustainable, holistic kidney care strategies. Further research and interdisciplinary collaboration are essential to validate and operationalize Ayurvedic interventions within the framework of evidence-based medicine.