Inflammation is a protective physiological response of the body to harmful stimuli such as pathogens, tissue injury, or irritation. In Ayurveda, inflammatory swelling is described under the concept of Shotha. Acharya Charaka described Shothahara Gana as one among the Mahakashayas (Dashemani), consisting of ten medicinal plants known for their ability to reduce swelling and inflammatory conditions³. Many of these plants constitute the classical Dashamoola group, widely used in Ayurvedic therapeutics⁴. The present article reviews the concept of Shotha, the composition of Shothahara Gana, pharmacological properties of individual drugs and their relevance in the management of inflammatory disorders.