ABSTRACT Jwara is considered one of the most significant disease conditions in Ayurveda due to its impact on both physical and mental health. Among the different varieties of Jwara, Vishama Jwara is characterized by irregular, intermittent, or periodic fever episodes. Classical Ayurvedic scholars have described the etiology, pathogenesis, and therapeutic approach of this condition in detail. The disease mainly arises due to impaired digestive fire leading to the formation of Ama and subsequent vitiation of Doshas. In many cases, Vishama Jwara presents clinical features similar to periodic febrile illnesses such as Malaria. The present review aims to compile and analyze classical descriptions of Vishama Jwara and highlight the therapeutic principles recommended in Ayurvedic literature. Understanding these principles provides insight into holistic approaches for the management of recurrent fevers.