Depression is a common and debilitating mental health disorder characterized by persistent sadness, loss of interest, fatigue, and cognitive impairment. In contemporary medicine, it is managed through pharmacotherapy and psychotherapy; however, limitations such as side effects, relapse, and incomplete recovery necessitate integrative approaches. Ayurveda conceptualizes mental health through the balance of Manasika Doshas (Rajas and Tamas) and emphasizes psychological therapies under Satvavajaya Chikitsa, one of the three principal treatment modalities described in classical texts. Satvavajaya Chikitsa, often translated as “mind control therapy,” focuses on restraining the mind from unwholesome objects and cultivating mental resilience through counseling, behavioral modification, and spiritual practices. This article explores the role of Satvavajaya Chikitsa in depression through classical Ayurvedic references and correlates it with modern psychological interventions. The study highlights its application in improving emotional stability, cognitive clarity, and overall well-being. The paper aims to establish Satvavajaya Chikitsa as an effective, non-pharmacological approach in the management of depression and advocates its integration into holistic healthcare models.