The research in the field of pharmaceutical sciences is fast developing and advance drug delivery systems are critical to the improvement in the therapeutic outcome, patient compliance, and dosing frequency reduction. Of these systems, there is a great concern with sustained release (SR) formulations since they also keep the plasma drug concentrations at a steady level. This does not only guarantee the extended pharmacological effect but also reduces the intervals of taking the drug and the side effects of pharmacological action. Among the products most frequently prescribed, where a sustained release preparation would be of great advantage, is Ibuprofen, a much used non-steroidal anti-inflammatory drug (NSAID) of relatively short half-life of about 2 hours circulating range.