Background-Chronic Kidney Disease (CKD) is a long-term condition in which the kidneys gradually lose their ability to function properly. The kidneys are essential for removing waste from the body, maintaining fluid and electrolyte balance, controlling blood pressure, and helping in the production of red blood cells. Worldwide, CKD affects over 10% of people and can eventually progress to kidney failure, requiring treatments like dialysis or kidney transplantation, which are costly and may not always be fully effective. Case Presentation: A 42-year-old woman presented with symptoms of frequent, foamy urination, tiredness, body swelling, and disturbed sleep, along with a history of poorly controlled high blood pressure. Laboratory investigations showed increased serum creatinine levels and a decreased estimated glomerular filtration rate (eGFR), consistent with stage 4 chronic kidney disease. Intervention: The patient was managed at Gopabandhu ayurveda Mahavidyalaya,puri, using Ayurvedic formulations including Trinapanchamoola Kashaya, Gokshiradi Guggulu,Neph-x, Neeri KFT syrup, and supportive in-house preparations. Treatment was complemented with a CKD-specific diet and lifestyle regimen. Clinical progress was tracked using serum creatinine, eGFR, hemoglobin, and blood glucose levels. Outcome: Over one and half months , significant improvements were recorded, including reduced serum creatinine, improved eGFR, and better overall well-being. Thus, it can be concluded that Ayurvedic approaches are helpful to manage CKD.