This research paper explores the reinterpretation and integration of Hindu philosophical concepts in Hermann Hesse’s Siddhartha. It examines how central ideas such as karma, dharma, samsara, moksha, and the unity of Atman and Brahman are woven into the narrative to depict the protagonist’s journey toward self-realization. The study highlights how Hesse adapts these concepts within a Western literary framework, thereby creating a cross-cultural philosophical discourse. Through close textual analysis, the paper argues that Siddhartha presents a universal spiritual quest that transcends religious boundaries while remaining deeply rooted in Hindu thought. It also evaluates the novel’s relevance in contemporary times, particularly in addressing existential crises and the search for meaning in modern life.