Background: Tundikeri is an important disease entity described under Mukha Roga in Ayurvedic classics, involving the oral cavity and throat. It has been variably classified by different Acharyas in various Ayurvedic classics, with some considering it as a Talugata Roga while others place it under Kanthagata Roga. This variation reflects the anatomical and pathological overlap between Talu and Kantha regions. Despite its clinical significance and resemblance to inflammatory conditions of the throat, a comprehensive theoretical understanding based on classical literature is essential for understanding anatomical, physiological and pathological characters as well as clinical and easy application of treatment principle.. Objective: To critically analyze and compile the classical Ayurvedic concept of Tundikeri with emphasis on Nidana Panchaka, Samprapti, and its fundamental pathological framework. Materials and Methods: The present study is a conceptual review based exclusively on classical Ayurvedic literature. Relevant descriptions from Brihatrayee, Laghutrayee, and other classical texts were systematically analyzed. The study focuses on anatomical aspects, Nidana, Samprapti, Kriyakala, clinical features, prognosis, and management principles. A comparative approach was adopted to consolidate variations among different Acharyas. Results: Tundikeri is identified as a Kapha-pradhana Shothaja Vyadhi with involvement of Rakta and Mamsa Dhatu. The disease originates from Kapha-aggravating dietary and lifestyle factors, leading to Agnimandya and Ama formation. Vitiated Doshas circulate through Rasavaha and Raktavaha Srotas and localize in Talu or Kantha due to Kha-vaigunya. This results in Dosha-Dushya Sammurchana, Srotorodha, and localized inflammatory swelling manifesting as Tundikeri. Classical descriptions emphasize features such as Shotha, Toda, Daha, and Paka. Conclusion: Tundikeri represents a classical Kapha-dominant inflammatory disorder with well-defined Samprapti. Understanding its Nidana Panchaka and Samprapti Ghataka provides a strong foundation for diagnosis and management. The disease highlights the integrative approach of Ayurveda involving Dosha, Dhatu, and Srotas in pathogenesis.