Liquid crystals are substances that flow like liquid but maintain some of the ordered structure characteristic of crystalline solid. Liquid crystal can be divided into thermotropic and lyotropic phase. The thermotropic is generated by temperature variation in the liquid state, whereas lyotropic is formed by dissolving the compound in certain solvents. The liquid crystal systems have some advantages such as drug solubilization level, drug degradation, biological and chemical sensing, stability of drug, control drug release, light, thin, sustained and controlled release pharmaceutical properties. Liquid crystal technology has had a major effect in many areas of science pharmacy and engineering, as well as device technology. The drug delivery to site of target can be achieved by using liquid crystal systems. Objective of this review is to provide information in development of targeted drug delivery system, depth information of pharmaceutical liquid crystal technology, its classification and application in the pharmaceutical field.