In the paper are discussed questions of the research to find new antagonistic microbes. The results obtained on the action of the investigated 5 microorganisms-antagonists (Bacillus megaterium, Bacillus brevis, Streptomyces sp Pseudomonas fluorescens, Bacillus thuregensis) to seven species of phytopathogenic microorganisms (Fusarium oxysporium, ) are presented in the article. On the basis of the received data the conclusion has been drawn that the revealed kinds to some extent possess defined, but the yielded strains in a kind of weak virulence cannot be applied in the practical purposes.