This study aimed to develop and evaluation of Do-It-Yourself (DIY) Science Projects Learner’s Material Guide in Paaralang Sekundarya ng Lucban Integrated School of SY 2020-2021. It sought to achieve the following objectives: Find out the level of acceptability of the DIY Science Projects Learner’s Material Guide in terms of appearance, content, usefulness, conformity, accuracy, clarity and originality. Determine the mean performance of the student-respondents in pretest and posttest. Find out the statistically significant difference in the achievement between the two groups of students in terms of pretest and posttest. Identify the perceived benefits of the students on the use of DIY Science Projects Learner’s Material Guide in their affective aspect. Quasi-experimental form of research was utilized in the study. Two Grade 10 sections with sixty-three (63) students each served as control and experimental groups. The tools in the study were subjected to analysis and validated by experts and statisticians. It was found out, DIY Science Projects Learner’s Material Guide in terms of appearance, content, usefulness, conformity, accuracy, clarity, and originality were all “highly acceptable” to teachers and students’ respondents. Posttest scores revealed that developed material is as effective as the implemented tool provided by DepEd in enhanc-ing students’ academic performance as seen from the result of their assessments. In addition, the use of DIY Science Projects Learner’s Material Guide in student’s affective aspect showed that both high and low performing students benefited. This means Science teachers may adopt developed material in delivering and improving lessons to the students in the New normal classroom or tie up with the local government units for the other possible DIY projects that may benefit the school and com-munity.