This study was entitled Comprehension Enhancer Activity Booklet as Innovative Instructional Material in Teaching Chemistry 8. The school where the researcher is teaching been the place used for the gathering of data, Gov. Felicisimo T. San Luis Integrated Senior High School. The respondents of the study were ten (10) Science teachers who validated the CEAB. This study was conducted during the Third Quarter of the School-Year 2020-2021.The researcher used input, process and output which represents the relationship among the variables used in the study. The input includes the selected topics in Chemistry 8, the process including the acceptability and validation of the CEAB as innovative instructional material in teaching Chemistry 8. And the output of the study is the CEAB as innovative instructional material in teaching Chemistry 8. The study is limited to the assessment whether the use of intervention materials is effective as an input. The level of acceptability and the difference between the pre-test and post-test mean scores with the use of comprehension enhancer activity booklet as innovative instructional material is investigated by this research. Descriptive method was used in this study to be able to answer the hypothesis based from what was observed. A survey questionnaire was utilized to gather data in determining the relationship of CEAB utilized by the teachers and third quarterly academic performance of the students.Teachers perceived that the use CEAB as innovative instructional material such as activities, content, creativity, design were very affective and these help them to enhance the performance in Chemistry 8 and they benefited from using comprehension enhancer activity booklet as innovative instructional material to easily understand the lesson. Moreover, there was a significant difference on the grade 8 students pre-test and post-test mean scores with the use of instructional material at 0.05 level of significance. It was recommended this research could also be used in other schools to further observe the importance enhancer activity booklet as innovative instructional material in teaching chemistry. This can make the researcher’s study more reliable as a larger population would allow for a better generalization of the data. Finally, feedbacks received should be take into consideration to determine the progress of the researchers in achieving their objectives. Shifting the study’s focus to interventions that rely on proactive approaches to resolve the issues will be a great follow-up for this study.