Ultrasonic velocity, density, and viscosity for Curcumin with primary alcohols binary mixture viz, I-propanol is determined at 303k using Ultrasonic Interferometer. The result shows values for thermodynamic parameters such as adiabatic compressibility, intermolecular free length, free volume, acoustic impedance, and the molecular association have been calculated and tabulated. The data are used study to correlate the properties and relevant interaction parameters with the nature of intermolecular interaction between the binary mixture compounds. The results show a nonlinear variation of acoustical parameters which confirms the presence of molecular associative nature.