FORMULATION AND EVALUATION OF SUSTAIN RELEASE MATRIX TABLETS OF VALSATRAN


D.Praveen, Dr.G.S Valluri, Dr.G.Vijaya Kumar
STUDENT, kgr institute
Abstract
The aim of present is to develop & evaluate extended release matrix tablet of Valsartan. Valsartan is an Hypotensive agents. But owing to its shorter half life it needs frequent administration. In present study, an attempt has been made to develop extended release matrix tablet of Valsartan there by reducing its frequency of administration & other dose related side effects. Different types of Eudragit S 100, Sodium CMC and HPMC K4M were used as polymers. Total 12 formulations were prepared in trial batches. The formulation was evaluated for various pre compression & post compression parameters. All the formulations showed compliance with the pharmacopoeial standards. On the basis of evaluated parameters formulation V8 was considered to be the best one. Formulation V8 containing polymer Sodium CMC showed 98.53 % invitro drug release profile. The release data for formulation V8 was fitted to various mathematical models like zero order, first order, Krosmeyer Peppas & Higuchi model. It was observed that drug follows Peppas release mechanism.
Keywords: Valsartan, Extended release system
Journal Name :
EPRA International Journal of Multidisciplinary Research (IJMR)

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Published on : 2021-11-03

Vol : 7
Issue : 11
Month : November
Year : 2021
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