With pronounced destructive changes in the basement membrane of the glomeruli, the urinary excretion of immunoglobulins-G and A increases. Therefore, the determination of the amount of serum immunoglobulins and their excretion in the urine is important. We carried out a study of the quantitative content of serum immunoglobulins of class A, M, G, as well as the relative content of T- and B lymphocytes in 24 children with glomerulonephritis and nephropathies of metabolic genesis at the age from 2 to 14 years. Immunoglobulins were determined by the method of radial immunodiffusion according to Mancini, T and B lymphocytes by the method of E - and EAC - rosette formation. The results obtained showed that in acute glomerulonephritis, there is a decrease in the level of IG-J and IG-A, respectively, 630 mg% and 130 mg% compared to the age norm: 1025 mg% and 160 mg%. IG-J -460mg% and IG-A -85%. All patients had high levels of immunoglobulin -M: 120 mg% with OHN and 155mg% with chronic renal failure compared with the age norm - 98mg%. Thus, the determination of the amount of serum immunoglobulins and the main subpopulations of lymphocytes is of great importance in understanding the essence of immune disorders and in choosing the correct therapy.