The political and military relations between Uzbekistan and the United States was at the peak during the period of 2001 through 2005. At the initiative of the first President of the Republic of Uzbekistan, Islam Karimov, the military airbase in southern Uzbekistan was leased out to the US for free use as a military base for its antiterrorist operations in Afghanistan. It is important to study the sudden end of the strategic partnership and cooperation between Uzbekistan and the United States in 2005. Because the study of the reasons for the termination of the agreement can be useful in the future in the development and continuation of foreign relations of both countries. The changing security environment, US strategic interests, domestic unrest, Islamic threats, presidential leadership, economic instability conditions and the resistance of Russia, economic assistance, alternative airports and local problems of K-2 variables have been analyzed and descriptively illuminated. The bandwagoning theory was used to explain this historical phenomenon. Bandwagoning occurs when a weaker state decides that the cost of opposing a stronger power exceeds the benefits. That is, weak states must comply with rules and standards in order to receive assistance from strong states. If they do not comply with rules and standards, there will be no bandwagoning and the strategic partnership will end.