The aim of this study was to assess the anxiety and locomotive activity using elevated plus maze and open field tests in a konzo induced rat model. An experimental research method was used in this study. 20 male Wistar rats were used for this study. The twenty (20) albino Wistar rats were randomly selected into four groups of five rats each. Animal feeding was by oral ingestion. Animals were weighed with an electric weighing scale and the weights were recorded. Animals were closely observed for physical manifestations and clinical signs. Group 1 was the control group and the rats were fed with water and feed, group 2 was fed bitter cassava, group 3 was fed with bitter cassava and complain milk, while group 4 was fed with bitter cassava and bambara nut. The study lasted for 4 weeks and during this period, the weight and neurobehavioral assessment was done using weighing balance for weight determination, elevated plus maze and open field test for neurobehavioral assessment. Data was analyzed using Statistical Package for the Social Sciences (SPSS IBM version 23.0) and Microsoft excel 2019 edition. Values were expressed as mean±SD in descriptive statistics. One-way analysis of variance (ANOVA) was used to analyze the difference between the groups followed by least significant difference (LSD) post-hoc test. Confidence interval was set at 95%, and therefore p<0.05 was considered significant. The result shows weekly body weight differences in experimental animals. There was significant weight reduction in the body weight of the Konzo induced group experimental Wistar rats from week 1 to week 4 compared to the significant weight increase observed in the Konzo induced and complan milk fed group Wistar rats. The result from elevated plus maze showed that there was an improvement in anxiety level of Wistar rats fed with complan and bambara nut in terms of the time spent in the sections of the elevated plus maze in week 2 when compared to the week 1. In evaluating the locomotion impairment and anxiety level of wistar rats using Open Field Test, cassava-induced Konzo Wistar rat group, cassava-induced Konzo and complan milk fed group Wistar rats group and cassava-induced Konzo and Bambara nut (Okpa) fed Wistar rats group spent significantly more time in the open field apparatus in week 2 when compared to week 1. The improvement in anxiety and locomotor activity indicates the ameliorative effect of complan milk and Bambara nut (Okpa) and this is due to the protein content of complan milk and bambara nut. Hence a balance diet/protein containing food should be eaten along cassava processed foods.