A positive work- life balance makes employees feel job satisfaction towards their work and increase their productivity. Good quality work- life balance will be reduced employee retention. This study aims to know the impact of work- life balance on job satisfaction of Hospital Nurses working in Private Hospitals in Mangalore City, Dakshina Kannada. Nursing profession is a multi-tasking job. So excessive work load and long hours shifts makes imbalance in work and family life of nurses. The sample used in this study is 100 respondents. The study is descriptive one. A structured questionnaire is prepared to collect data from 100 respondents. The collected data was analyzed and thereby suggestions & conclusion are drawn.