The fruit fly (Drosophila melanogaster) has long been a premier model for developmental biologists and geneticists. The utility of Drosophila for toxicology studies has only recently gained broader recognition as a tool to elaborate molecular genetic mechanisms of toxic substances. The common fruit fly, Drosophila melanogaster, has been considerably studied for decades. In effect, it was introduced as a decisive model in biology about a century agone. The fly shares several introductory natural, biochemical, neurological and physiological parallels with mammals. It’s proved that about 75% of mortal complaint-causing genes have functional homolog in D. melanogaster. The fly can effectively be maintained at low cost in the laboratory, and it has been recommended as an indispensable model to invertebrate operation. Accordingly, it has attracted the interest of toxicologists. In the present review, we presented and bandied the openings available to toxicologists who wish to use D. melanogaster as a model to study neurodegenerative consequences, oxidative stress and antioxidant labels, cancer, inflammation and metabolic diseases. We also included key information similar as the FlyBase resource that will help toxicologists interested in using fruit flies as an indispensable organism to other organism models.