A Study Evaluate the effectiveness of structured teaching programme on knowledge and attitude regarding lifestyle modifications among patients undergoing dialysis in selected hospital at salem, Tamilnadu. Objectives  To assess the level of knowledge and attitude regarding lifestyle modifications among patients undergoing dialysis.  To administer a structured teaching programme on lifestyle modifications among patients undergoing dialysis.  To assess the effectiveness of structured teaching programme on the level of knowledge and verbal responses structured interview schedule for attitude regarding lifestyle modifications among patients undergoing dialysis.  To find out the correlation between knowledge and attitude regarding lifestyle modifications among patients undergoing dialysis.  To find out the association between knowledge and attitude regarding lifestyle modifications among patients undergoing dialysis with selected demographic variables. Methodology One group pretest and posttest experimental research design. 80 samples were selected using non-probability convenient sampling. A structured Knowledge questionnaire was used to assess the knowledge and modified Likert Scale was used to assess the attitude. Descriptive and inferential statistics were used to analyze the data. Conclusion The study findings revealed that the structured teaching programme regarding lifestyle modifications improved the knowledge and thereby modified the favorable attitude of chronic kidney disease patients. The obtained ‘t’ value for comparison of knowledge score at p<0.05 was 16.87and the obtained ‘t’ value for comparison of attitude scores at p<0.05 level was 18.87. There was a positive correlation found between the knowledge and attitude scores in the pre-and post test. The study also revealed that that there was an association between the pretest level of knowledge scores and the education, but, other variables like age, sex, religion, occupation. Income, marital status, type of family, dietary pattern, duration of disease, personal habits, associated illness were not associated with the pretest level of knowledge scores. Further, there was no association found between pretest level of attitude scores with the selected demographic variables.