The article discusses changes in the parasite fauna of some fish species in the lower reaches of the river. Amu Darya. The latest data on the parasite fauna of 4 species of indigenous commercial fish of the lower reaches of the river are presented. Amudarya in the conditions of a degraded natural environment (2014-2019). The depletion of the fauna of ichthyoparasites under the influence of the ongoing anthropogenic pressure and its causes is shown. Species of parasites with constant high infection and pathogenic forms, which are potential pathogens of fish diseases and extreme environmental conditions of the region, are indicated.