The aim of this study is to determine the effect of chlorhexidine mouth rinse after placement of dental implants. A systematic review was conducted based on a literature search in the databases PubMed, Cochrane library, Elsevier science direct, Wiley online library, grey literature, Ovid Medline using the search keywords (chlorhexidine mouth rinse) AND (placement) AND (dental implants). Randomised controlled trials investigating the effect of Chlorhexidine mouth rinse and further followed by Cochrane database bias assessment was done. Four randomised controlled trials were included, and after discussed, the result of the p-value is significant in chlorhexidine mouth rinse after placement of dental implants. The use of chlorhexidine mouth rinse will reduce dental plaque control for gingivitis after placement of a dental implant. Chlorhexidine mouth rinse influences wound healing at the placement of a dental implant.