The field experiment was conducted to determine the influence of organic, mineral fertilizers and biopreparations on cotton yield in saline soil condition of the Republic of Karakalpakstan. On the basis of the information received from the experiment it was defined that the yield is high when organic fertilizer is decreased to 1,0 t/ha, mineral fertilizer 25% in fedding cotton, used in the amount of N180 P130 K90 kg/ha and from biopreparations Phytovak was applied in the amount of 2 l/ha 3 times. When organic fertilizer in the amount of 40 t/ha, mineral fertilizer – N185 P130 K90 kg/ha and biopreparation – 2 l/ha 3 times, it was provided to receive 37,3 q/ha yield.