Multiple sclerosis is a disease that is characterized by the nervous system injury. The pathophysiology is unknown, but it is supposed that it is caused by an increase of the immune response to the myelin sheath, which causes damage in the nervous system. Actually, there are a lot of immunomodulatory drugs to control this pathology. One of the most important aspects of this disease is the fact that it is irreversible; therefore, the use of drugs for this illness is just for the control of the symptoms; nevertheless, some review has shown the free-recurrency of multiple sclerosis. Nowaday, there is information that defines the effectiveness of Rituximab, Alemtuzumab, Fingolimod, and many more drugs. In the non-pharmacological aspects, there is information about the diet and its non-action in the progression of Multiple Sclerosis. When a patient presents fatigue, there are many alternatives for the control of this. Finally, activities which stimulate social interactions have shown little effectiveness in these patients.