Aim: To assess the effectiveness of Lycopene as one of the interventions for the treatment of periodontitis. Methodology: A systematic review of controlled trials was performed. Electronic and hand searches retrieved 186 records, and 184 were screened. Three studies were included in this systematic review. The intervention and outcomes were assessed in the study included in the systematic review. Result: Three results were included in the systemic review, of which all are clinical trials. Where Lycopene shows efficacy in the treatment of periodontitis. The outcome and results were positive in the studies above, showing that Lycopene significantly reduces probing depth, bleeding on probing, and reduction in plaque. Conclusion: In the present study, the applicable confirmation recommends that Lycopene may be competent in the management of periodontitis. The studies revealed that Lycopene is a promising candidate in the treatment of periodontitis as an anti-oxidative therapy.