Guillain-Barre is one of the most common syndromes causing acute flaccid paralysis worldwide, usually starting with a motor component and spreading upwards; the most common organism causing this pathology is Campylobacter Jejuni. However, due to the pandemic, the presence of this neurological pathology has been reported in patients with SARS-CoV2. The process by which this disease is produced is due to the interaction between the immunological processes produced by the activation of autoantibodies that triggers an affection at the level of the peripheral nerves(1)(2)(3). In this literature review, we intend to mention the scientific evidence related to the presence of the coronavirus (or COVID-19 vaccines) and its relationship with Guillain-Barre disease.