This study investigates Pentecostals perceptions and practices towards the COVID 19 preventive measures as instituted by the government of Cameroon. In the study we used the case study design emphasizing the qualitative research method with the techniques of observation and interview used to collect data. The sample population was chosen using the purposeful sampling technique. Five influential Pentecostal churches of above 500 congregants each Sunday, with television channels, and/or educational institutions chosen and informants selected from the five churches. At the end of our study, we discovered that the Pentecostals beliefs system and their perceptions of COVID 19 influenced their practices in their control of the pandemic.